The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system

BACKGROUND: Previous studies have demonstrated that intrathecal administration of the substance P amino-terminal metabolite substance P(1-7 )(SP(1-7)) and its C-terminal amidated congener induced antihyperalgesic effects in diabetic mice. In this study, we studied a small synthetic dipeptide related...

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Detalhes bibliográficos
Main Authors: Ohsawa, Masahiro, Carlsson, Anna, Asato, Megumi, Koizumi, Takayuki, Nakanishi, Yuki, Fransson, Rebecca, Sandström, Anja, Hallberg, Mathias, Nyberg, Fred, Kamei, Junzo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225307/
https://ncbi.nlm.nih.gov/pubmed/22040520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-85
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