Structural Modification of Pantothenamides Counteracts Degradation by Pantetheinase and Improves Antiplasmodial Activity

[Image: see text] Pantothenamides are secondary or tertiary amides of pantothenic acid, the vitamin precursor of the essential cofactor and universal acyl carrier coenzyme A. A recent study has demonstrated that pantothenamides inhibit the growth of blood-stage Plasmodium falciparum with submicromol...

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Auteurs principaux: de Villiers, Marianne, Macuamule, Cristiano, Spry, Christina, Hyun, Yoo-Min, Strauss, Erick, Saliba, Kevin J.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2013
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027574/
https://ncbi.nlm.nih.gov/pubmed/24900746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400180d
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