4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors

[Image: see text] A series of 2-hydroxy-1,3-dioxoisoquinoline-4-carboxamides featuring an N-hydroxyimide chelating functionality was evaluated for their inhibitory properties against human immunodeficiency virus type 1 integrase (HIV-1 IN). Several derivatives displayed low nanomolar IC(50) values c...

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Detalhes bibliográficos
Main Authors: Billamboz, Muriel, Suchaud, Virginie, Bailly, Fabrice, Lion, Cedric, Demeulemeester, Jonas, Calmels, Christina, Andréola, Marie-Line, Christ, Frauke, Debyser, Zeger, Cotelle, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027527/
https://ncbi.nlm.nih.gov/pubmed/24900718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400009t
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