Structure–Activity Relationships and in Vivo Evaluation of Quinoxaline Derivatives for PET Imaging of β-Amyloid Plaques

[Image: see text] This letter describes the synthesis, structure–activity relationships, and in vivo evaluation of a new series of 2-phenylquinoxaline (PQ) derivatives for imaging β-amyloid (Aβ) plaques in Alzheimer’s disease (AD). In experiments in vitro, the affinity of the derivatives for Aβ aggr...

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Main Authors: Yoshimura, Masashi, Ono, Masahiro, Matsumura, Kenji, Watanabe, Hiroyuki, Kimura, Hiroyuki, Cui, Mengchao, Nakamoto, Yuji, Togashi, Kaori, Okamoto, Yoko, Ihara, Masafumi, Takahashi, Ryosuke, Saji, Hideo
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027474/
https://ncbi.nlm.nih.gov/pubmed/24900717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4000707
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