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BODIPY-Based Molecular Probe for Imaging of Cerebral β-Amyloid Plaques

[Image: see text] We designed and synthesized a BODIPY-based probe (BAP-1) for the imaging of β-amyloid plaques in the brain. In binding experiments in vitro, BAP-1 showed excellent affinity for synthetic Aβ aggregates. β-Amyloid plaques in Tg2576 mouse brain were clearly visualized with BAP-1. In a...

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Bibliografische gegevens
Hoofdauteurs: Ono, Masahiro, Watanabe, Hiroyuki, Kimura, Hiroyuki, Saji, Hideo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2012
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369805/
https://ncbi.nlm.nih.gov/pubmed/22860198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn3000058
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