Synthesis and Evaluation of Novel Chalcone Derivatives with (99m)Tc/Re Complexes as Potential Probes for Detection of β-Amyloid Plaques

[Image: see text] Four (99m)Tc-labeled chalcone derivatives and their corresponding rhenium analogues were tested as potential probes for imaging β-amyloid plaques. The chalcones showed higher affinity for Aβ(1−42) aggregates than did (99m)Tc complexes. In sections of brain tissue from an animal mod...

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Autors principals: Ono, Masahiro, Ikeoka, Ryoichi, Watanabe, Hiroyuki, Kimura, Hiroyuki, Fuchigami, Takeshi, Haratake, Mamoru, Saji, Hideo, Nakayama, Morio
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2010
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368688/
https://ncbi.nlm.nih.gov/pubmed/22778849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn100042d
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