Structure-Based Design of 2-Aminopyridine Oxazolidinones as Potent and Selective Tankyrase Inhibitors

[Image: see text] Aberrant activation of the Wnt pathway has been implicated in the development and formation of many cancers. TNKS inhibition has been shown to antagonize Wnt signaling via Axin stabilization in APC mutant colon cancer cell lines. We employed structure-based design to identify a ser...

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Autors principals: Huang, Hongbing, Guzman-Perez, Angel, Acquaviva, Lisa, Berry, Virginia, Bregman, Howard, Dovey, Jennifer, Gunaydin, Hakan, Huang, Xin, Huang, Liyue, Saffran, Doug, Serafino, Randy, Schneider, Steve, Wilson, Cindy, DiMauro, Erin F.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027438/
https://ncbi.nlm.nih.gov/pubmed/24900633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4003315
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