Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor

[Image: see text] The modulation of LRRK2 kinase activity by a selective small molecule inhibitor has been proposed as a potentially viable treatment for Parkinson's disease. By using aminopyrazoles as aniline bioisosteres, we discovered a novel series of LRRK2 inhibitors. Herein, we describe o...

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Main Authors: Chan, Bryan K., Estrada, Anthony A., Chen, Huifen, Atherall, John, Baker-Glenn, Charles, Beresford, Alan, Burdick, Daniel J., Chambers, Mark, Dominguez, Sara L., Drummond, Jason, Gill, Andrew, Kleinheinz, Tracy, Le Pichon, Claire E., Medhurst, Andrew D., Liu, Xingrong, Moffat, John G., Nash, Kevin, Scearce-Levie, Kimberly, Sheng, Zejuan, Shore, Daniel G., Van de Poël, Hervé, Zhang, Shuo, Zhu, Haitao, Sweeney, Zachary K.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2012
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027423/
https://ncbi.nlm.nih.gov/pubmed/24900567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3003007
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