New Promising Compounds with in Vitro Nanomolar Activity against Trypanosoma cruzi

[Image: see text] The antiparasitic activity of azole and new 4-aminopyridine derivatives has been investigated. The imidazoles 1 and 3–5 showed a potent in vitro antichagasic activity with IC(50) values in the low nanomolar concentration range. The (S)-1, (S)-3, and (S)-5 enantiomers showed (up to)...

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Main Authors: Friggeri, Laura, Scipione, Luigi, Costi, Roberta, Kaiser, Marcel, Moraca, Francesca, Zamperini, Claudio, Botta, Bruno, Di Santo, Roberto, De Vita, Daniela, Brun, Reto, Tortorella, Silvano
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2013
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027138/
https://ncbi.nlm.nih.gov/pubmed/24900706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400039r
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