Efficient Electrochemical N-Alkylation of N-Boc-Protected 4-Aminopyridines: Towards New Biologically Active Compounds

The use of electrogenerated acetonitrile anion allows the alkylation of N-Boc-4-aminopyridine in very high yields, under mild conditions and without by-products. The high reactivity of this base is due to its large tetraethylammonium counterion, which leaves the acetonitrile anion “naked.” The depro...

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Detalhes bibliográficos
Main Authors: Feroci, Marta, Chiarotto, Isabella, Forte, Gianpiero, Simonetti, Giovanna, D'Auria, Felicia Diodata, Maes, Louis, De Vita, Daniela, Scipione, Luigi, Friggeri, Laura, Di Santo, Roberto, Tortorella, Silvano
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041018/
https://ncbi.nlm.nih.gov/pubmed/24955255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/621592
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