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Light Activation of a Cysteine Protease Inhibitor: Caging of a Peptidomimetic Nitrile with Ru(II)(bpy)(2)
A novel method for caging protease inhibitors is described. The complex [Ru(II)(bpy)(2)(1)(2)](PF(6))(2) (2) was prepared from the nitrile-based peptidomimetic inhibitor Ac-Phe-NHCH(2)CN (1). (1)H NMR, UV-vis and IR spectroscopic and mass spectrometric data confirm that two equiv of inhibitor 1 bind...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027032/ https://ncbi.nlm.nih.gov/pubmed/21973207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja208084s |
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