Inhibition of Cathepsin Activity in a Cell-Based Assay by a Light-Activated Ruthenium Compound

Light-activated inhibition of cathepsin activity was demonstrated with in a cell-based assay. Inhibitors of cathepsin K, Cbz-Leu-NHCH(2)CN (2) and Cbz-Leu-Ser(OBn)-CN (3), were caged within the complexes cis-[Ru(bpy)(2)(2)(2)]Cl(2) (4) and cis-[Ru(bpy)(2)(3)(2)](BF(4))(2) (5), where bpy = 2,2′-bipyr...

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Main Authors: Respondek, Tomasz, Sharma, Rajgopal, Herroon, Mackenzie K., Garner, Robert N., Knoll, Jessica D., Cueny, Eric, Turro, Claudia, Podgorski, Izabela, Kodanko, Jeremy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4095795/
https://ncbi.nlm.nih.gov/pubmed/24729544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201400081
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