Affnity-Enhanced Luminescent Re(I)- and Ru(II)-Based Inhibitors of the Cysteine Protease Cathepsin L

Two new Re(I)- and Ru(II)-based inhibitors were synthesized with the formulas [Re(phen)(CO)(3)(1)](OTf) (7; phen = 1,10-phenanthroline, OTf = trifluoromethanesulfonate) and [Ru(bpy)(2)(2)](Cl)(2) (8; bpy = 2,2′-bipyridine), where 1 and 2 are the analogues of CLIK-148, an epoxysuccinyl-based cysteine...

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Publicado en:Inorg Chem
Main Authors: Huisman, Matthew, Kodanko, Jacob P., Arora, Karan, Herroon, Mackenzie, Alnaed, Marim, Endicott, John, Podgorski, Izabela, Kodanko, Jeremy J.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034508/
https://ncbi.nlm.nih.gov/pubmed/29882662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.inorgchem.8b00978
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