Učitavanje...
Modeling conformational transitions in kinases by molecular dynamics simulations: achievements, difficulties, and open challenges
Protein kinases work because their flexibility allows to continuously switch from inactive to active form. Despite the large number of structures experimentally determined in such states, the mechanism of their conformational transitions as well as the transition pathways are not easily to capture....
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4026744/ https://ncbi.nlm.nih.gov/pubmed/24860596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00128 |
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