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The open state of human topoisomerase I as probed by molecular dynamics simulation

The open state of human topoisomerase I has been probed by molecular dynamics simulation, starting from the coordinates of the closed structure of the protein complexed with DNA, after elimination of the 22-bp DNA duplex oligonucleotide. A repulsion force between the two lips of the protein has been...

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Bibliografiske detaljer
Main Authors: Chillemi, Giovanni, Bruselles, Alessandro, Fiorani, Paola, Bueno, Susana, Desideri, Alessandro
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1888835/
https://ncbi.nlm.nih.gov/pubmed/17439970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm199
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