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Transitions between Closed and Open Conformations of TolC: The Effects of Ions in Simulations

Bacteria, such as Escherichia coli, use multidrug efflux pumps to export toxic substrates through their cell membranes. Upon formation of an efflux pump, the aperture of its outer membrane protein TolC opens and thereby enables the extrusion of substrate molecules. The specialty of TolC is its abili...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Schulz, Robert, Kleinekathöfer, Ulrich
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Biophysical Society 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718315/
https://ncbi.nlm.nih.gov/pubmed/19383457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.01.021
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