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Gating at Both Ends and Breathing in the Middle: Conformational Dynamics of TolC
Drug extrusion via efflux through a tripartite complex (an inner membrane pump, an outer membrane protein, and a periplasmic protein) is a widely used mechanism in Gram-negative bacteria. The outer membrane protein (TolC in Escherichia coli; OprM in Pseudomonas aeruginosa) forms a tunnel-like pore t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2599845/ https://ncbi.nlm.nih.gov/pubmed/18835894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.136028 |
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