Gating at Both Ends and Breathing in the Middle: Conformational Dynamics of TolC

Drug extrusion via efflux through a tripartite complex (an inner membrane pump, an outer membrane protein, and a periplasmic protein) is a widely used mechanism in Gram-negative bacteria. The outer membrane protein (TolC in Escherichia coli; OprM in Pseudomonas aeruginosa) forms a tunnel-like pore t...

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Bibliographic Details
Main Authors: Vaccaro, Loredana, Scott, Kathryn A., Sansom, Mark S. P.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2008
Subjects:
Biophysical Theory and Modeling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2599845/
https://ncbi.nlm.nih.gov/pubmed/18835894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.136028
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