Ryanodine-Receptor Mediated Calcium Leak Drives Progressive Development of an Atrial Fibrillation Substrate in a Transgenic Mouse Model

BACKGROUND: The progression of atrial fibrillation (AF) from paroxysmal to persistent forms remains a major clinical challenge. Abnormal sarcoplasmic reticulum (SR) Ca(2+)-leak via the ryanodine receptor (RyR2) has been observed as a source of ectopic activity in various AF models. However, its pote...

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Bibliographic Details
Main Authors:	Li, Na, Chiang, David Y., Wang, Sufen, Wang, Qiongling, Sun, Liang, Voigt, Niels, Respress, Jonathan L., Ather, Sameer, Skapura, Darlene G., Jordan, Valerie K., Horrigan, Frank T., Schmitz, Wilhelm, Müller, Frank U., Valderrabano, Miguel, Nattel, Stanley, Dobrev, Dobromir, Wehrens, Xander H.T.
Format:	Artigo
Language:	Inglês
Published:	2014
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4026172/ https://ncbi.nlm.nih.gov/pubmed/24398018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.006611
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Ryanodine-Receptor Mediated Calcium Leak Drives Progressive Development of an Atrial Fibrillation Substrate in a Transgenic Mouse Model

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