Ryanodine-Receptor Mediated Calcium Leak Drives Progressive Development of an Atrial Fibrillation Substrate in a Transgenic Mouse Model

BACKGROUND: The progression of atrial fibrillation (AF) from paroxysmal to persistent forms remains a major clinical challenge. Abnormal sarcoplasmic reticulum (SR) Ca(2+)-leak via the ryanodine receptor (RyR2) has been observed as a source of ectopic activity in various AF models. However, its pote...

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Detalhes bibliográficos
Main Authors: Li, Na, Chiang, David Y., Wang, Sufen, Wang, Qiongling, Sun, Liang, Voigt, Niels, Respress, Jonathan L., Ather, Sameer, Skapura, Darlene G., Jordan, Valerie K., Horrigan, Frank T., Schmitz, Wilhelm, Müller, Frank U., Valderrabano, Miguel, Nattel, Stanley, Dobrev, Dobromir, Wehrens, Xander H.T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026172/
https://ncbi.nlm.nih.gov/pubmed/24398018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.006611
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