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Computational Analysis of the Binding Specificity of Gleevec to Abl, c-Kit, Lck, and c-Src Tyrosine Kinases

Gleevec, a well-known cancer therapeutic agent, is an effective inhibitor of several tyrosine kinases, including Abl and c-Kit. But it displays less potency to inhibit closely homologous tyrosine kinases, such as Lck and c-Src. Because many structural features of the binding site are highly conserve...

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Sonraí Bibleagrafaíochta
Main Authors: Lin, Yen-Lin, Roux, Benoît
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026022/
https://ncbi.nlm.nih.gov/pubmed/24001034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja405939x
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