β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine

[Image: see text] The cysteine amidase N-acylethanolamine acid amidase (NAAA) is a member of the N-terminal nucleophile class of enzymes and a potential target for anti-inflammatory drugs. We investigated the mechanism of inhibition of human NAAA by substituted β-lactones. We characterized pharmacol...

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Autors principals: Armirotti, Andrea, Romeo, Elisa, Ponzano, Stefano, Mengatto, Luisa, Dionisi, Mauro, Karacsonyi, Claudia, Bertozzi, Fabio, Garau, Gianpiero, Tarozzo, Glauco, Reggiani, Angelo, Bandiera, Tiziano, Tarzia, Giorgio, Mor, Marco, Piomelli, Daniele
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025845/
https://ncbi.nlm.nih.gov/pubmed/24900487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300056y
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