Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

[Image: see text] Fused oxadiazines (3) were discovered as selective and orally bioavailable γ-secretase modulators (GSMs) based on the structural framework of oxadiazoline GSMs. Although structurally related, initial modifications showed that structure–activity relationships (SARs) did not translat...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Huang, Xianhai, Zhou, Wei, Liu, Xiaoxiang, Li, Hongmei, Sun, George, Mandal, Mihirbaran, Vicarel, Monica, Zhu, Xiaohong, Bennett, Chad, McCraken, Troy, Pissarnitski, Dmitri, Zhao, Zhiqiang, Cole, David, Gallo, Gioconda, Zhu, Zhaoning, Palani, Anandan, Aslanian, Robert, Clader, John, Czarniecki, Michael, Greenlee, William, Burnett, Duane, Cohen-Williams, Mary, Hyde, Lynn, Song, Lixin, Zhang, Lili, Chu, Inhou, Buevich, Alexei
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2012
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025817/
https://ncbi.nlm.nih.gov/pubmed/24900409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300209g
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker