Novel 4-Aminoquinoline-Pyrimidine Based Hybrids with Improved in Vitro and in Vivo Antimalarial Activity

[Image: see text] A class of hybrid molecules consisting of 4-aminoquinoline and pyrimidine were synthesized and tested for antimalarial activity against both chloroquine (CQ)-sensitive (D6) and chloroquine (CQ)-resistant (W2) strains of Plasmodium falciparum through an in vitro assay. Eleven hybrid...

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Detalhes bibliográficos
Main Authors: Manohar, Sunny, Rajesh, U. Chinna, Khan, Shabana I., Tekwani, Babu L., Rawat, Diwan S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025768/
https://ncbi.nlm.nih.gov/pubmed/24900509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3000808
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