Hybridization of Fluoro-amodiaquine (FAQ) with Pyrimidines: Synthesis and Antimalarial Efficacy of FAQ–Pyrimidines

[Image: see text] To evade the possible toxicity associated with the formation of quinone-imine metabolite in amodiaquine (AQ), the para-hydroxyl group was replaced with a −F atom, and the resulting 4′-fluoro-amodiaquine (FAQ) was hybridized with substituted pyrimidines. The synthesized FAQ–pyrimidi...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Tripathi, Mohit, Taylor, Dale, Khan, Shabana I., Tekwani, Babu L., Ponnan, Prija, Das, Ujjalkumar Subhash, Velpandian, Thirumurthy, Rawat, Diwan S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511959/
https://ncbi.nlm.nih.gov/pubmed/31097988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00496
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