A Phenotypic High Throughput Screening Assay for the Identification of Pharmacoperones for the Gonadotropin Releasing Hormone Receptor

We describe a phenotypic high throughput screening (HTS) calcium flux assay designed to identify pharmacoperones for the gonadotropin releasing hormone receptor (GnRHR). Pharmacoperones are target-specific, small molecules that diffuse into cells, rescue misfolded protein mutants, and restore them t...

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Autori principali: Conn, P. Michael, Smith, Emery, Spicer, Timothy, Chase, Peter, Scampavia, Louis, Janovick, Jo Ann
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2014
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025569/
https://ncbi.nlm.nih.gov/pubmed/24831790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2014.576
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