Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation

p53 is a well-known tumor suppressor that is mutated in over 50% of human cancers. These mutations were shown to exhibit gain of oncogenic function compared with the deletion of the gene. Additionally, p53 has fundamental roles in differentiation and development; nevertheless, mutant p53 mice are vi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rivlin, Noa, Katz, Shir, Doody, Maayan, Sheffer, Michal, Horesh, Stav, Molchadsky, Alina, Koifman, Gabriela, Shetzer, Yoav, Goldfinger, Naomi, Rotter, Varda, Geiger, Tamar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2014
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024907/
https://ncbi.nlm.nih.gov/pubmed/24778235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320428111
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