A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

Misfolded ER proteins are retrotranslocated into the cytosol for degradation via the ubiquitin–proteasome system. The human cytomegalovirus protein US11 exploits this ER-associated protein degradation (ERAD) pathway to downregulate HLA class I molecules in virus-infected cells, thereby evading elimi...

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Main Authors: van de Weijer, Michael L., Bassik, Michael C., Luteijn, Rutger D., Voorburg, Cornelia M., Lohuis, Mirjam A.M., Kremmer, Elisabeth, Hoeben, Rob C., LeProust, Emily M., Chen, Siyuan, Hoelen, Hanneke, Ressing, Maaike E., Patena, Weronika, Weissman, Jonathan S., McManus, Michael T., Wiertz, Emmanuel J.H.J., Lebbink, Robert Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024746/
https://ncbi.nlm.nih.gov/pubmed/24807418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4832
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