Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)

[Image: see text] A structure-guided design approach using a homology model of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) was used to improve the potency of a series of imidazopyridazine inhibitors as potential antimalarial agents. This resulted in high affinity compounds wit...

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Auteurs principaux: Chapman, Timothy M., Osborne, Simon A., Wallace, Claire, Birchall, Kristian, Bouloc, Nathalie, Jones, Hayley M., Ansell, Keith H., Taylor, Debra L., Clough, Barbara, Green, Judith L., Holder, Anthony A.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2014
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024065/
https://ncbi.nlm.nih.gov/pubmed/24689770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500342d
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