Dronedarone, an Amiodarone Analog with Improved Anti-Leishmania mexicana Efficacy

Dronedarone and amiodarone are cationic lipophilic benzofurans used to treat cardiac arrhythmias. They also have activity against the parasitic protozoan Trypanosoma cruzi, the causative agent of Chagas' disease. They function by disrupting intracellular Ca(2+) homeostasis of the parasite and b...

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Hauptverfasser: Benaim, Gustavo, Casanova, Paola, Hernandez-Rodriguez, Vanessa, Mujica-Gonzalez, Sheira, Parra-Gimenez, Nereida, Plaza-Rojas, Lourdes, Concepcion, Juan Luis, Liu, Yi-Liang, Oldfield, Eric, Paniz-Mondolfi, Alberto, Suarez, Alirica I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
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Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023776/
https://ncbi.nlm.nih.gov/pubmed/24492373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01240-13
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