Amiodarone Destabilizes Intracellular Ca(2+) Homeostasis and Biosynthesis of Sterols in Leishmania mexicana

Leishmaniasis represents a serious public health problem worldwide. The first line of treatment is based on glucantime and pentostan, which generate toxic effects in treated patients. We have recently shown that amiodarone, frequently used as an antiarrhythmic, possesses activity against Trypanosoma...

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Asıl Yazarlar: Serrano-Martín, Xenón, García-Marchan, Yael, Fernandez, Alexis, Rodriguez, Noris, Rojas, Hector, Visbal, Gonzalo, Benaim, Gustavo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2009
Konular:
Mechanisms of Action: Physiological Effects
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663059/
https://ncbi.nlm.nih.gov/pubmed/19164149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01215-08
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