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Dronedarone, an Amiodarone Analog with Improved Anti-Leishmania mexicana Efficacy

Dronedarone and amiodarone are cationic lipophilic benzofurans used to treat cardiac arrhythmias. They also have activity against the parasitic protozoan Trypanosoma cruzi, the causative agent of Chagas' disease. They function by disrupting intracellular Ca(2+) homeostasis of the parasite and b...

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Detalhes bibliográficos
Main Authors: Benaim, Gustavo, Casanova, Paola, Hernandez-Rodriguez, Vanessa, Mujica-Gonzalez, Sheira, Parra-Gimenez, Nereida, Plaza-Rojas, Lourdes, Concepcion, Juan Luis, Liu, Yi-Liang, Oldfield, Eric, Paniz-Mondolfi, Alberto, Suarez, Alirica I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023776/
https://ncbi.nlm.nih.gov/pubmed/24492373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01240-13
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