Selective Target Inactivation Rather than Global Metabolic Dormancy Causes Antibiotic Tolerance in Uropathogens

Persister cells represent a multidrug-tolerant (MDT), physiologically distinct subpopulation of bacteria. The ability of these organisms to survive lethal antibiotic doses raises concern over their potential role in chronic disease, such as recurrent urinary tract infection (RUTI). Persistence is be...

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Hlavní autoři: Goneau, Lee W., Yeoh, Nigel S., MacDonald, Kyle W., Cadieux, Peter A., Burton, Jeremy P., Razvi, Hassan, Reid, Gregor
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Susceptibility
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023725/
https://ncbi.nlm.nih.gov/pubmed/24449771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02552-13
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