Antifolate Agents Against Wild and Mutant Strains of Plasmodium falciparum

Plasmodium falciparum dihydrofolate reductase is an important target for antimalarial chemotherapy. The emergence of resistance has significantly reduced the efficacy of the classic antifolate drugs cycloguanil and pyrimethamine. In this paper we report new dihydrofolate reductase inhibitors identif...

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Main Authors: Shaikh, M. S., Rana, J., Gaikwad, D., Leartsakulpanich, U., Ambre, Premlata K., Pissurlenkar, R. R. S., Coutinho, E. C.
Format: Artigo
Sprog:Inglês
Udgivet: Medknow Publications & Media Pvt Ltd 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023280/
https://ncbi.nlm.nih.gov/pubmed/24843184
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