Heterologous Src Homology 4 Domains Support Membrane Anchoring and Biological Activity of HIV-1 Nef

The HIV-1 pathogenicity factor Nef enhances viral replication by modulation of multiple host cell transport and signaling pathways. Nef associates with membranes via an N-terminal Src homology 4 (SH4) domain, and membrane association is believed to be essential for its biological functions. At which...

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Bibliographic Details
Main Authors: Geist, Miriam M., Pan, Xiaoyu, Bender, Silke, Bartenschlager, Ralf, Nickel, Walter, Fackler, Oliver T.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022873/
https://ncbi.nlm.nih.gov/pubmed/24706755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.563528
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