HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality

A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity and mortality. A subset of HIV-infected adults receiving effective antiretroviral therapy (ART) fails to normalize this ratio, even after they achieve normal CD4+ T cell counts. The immunologic and clinical c...

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Main Authors: Serrano-Villar, Sergio, Sainz, Talia, Lee, Sulggi A., Hunt, Peter W., Sinclair, Elizabeth, Shacklett, Barbara L., Ferre, April L., Hayes, Timothy L., Somsouk, Ma, Hsue, Priscilla Y., Van Natta, Mark L., Meinert, Curtis L., Lederman, Michael M., Hatano, Hiroyu, Jain, Vivek, Huang, Yong, Hecht, Frederick M., Martin, Jeffrey N., McCune, Joseph M., Moreno, Santiago, Deeks, Steven G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022662/
https://ncbi.nlm.nih.gov/pubmed/24831517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004078
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