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Spectroscopic, steady-state kinetic, and mechanistic characterization of the radical SAM enzyme QueE, which catalyzes a complex cyclization reaction in the biosynthesis of 7-deazapurines

7-Carboxy-7-deazaguanine (CDG) synthase (QueE) catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH(4)) to CDG in the third step of the biosynthetic pathway to all 7-deazapurines. Here we present a detailed characterization of QueE from Bacillus s...

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Detaylı Bibliyografya
Asıl Yazarlar: McCarty, Reid M., Krebs, Carsten, Bandarian, Vahe
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022186/
https://ncbi.nlm.nih.gov/pubmed/23194065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301156w
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