Analysis of the Benzene Oxide-DNA Adduct 7-Phenylguanine by Liquid Chromatography-Nanoelectrospray Ionization-High Resolution Tandem Mass Spectrometry-Parallel Reaction Monitoring: Application to DNA from Exposed Mice and Humans

Benzene oxide, the initial metabolite of the human carcinogen benzene, reacts with DNA producing 7-phenylguanine (7-PhG) and other products. We developed a highly sensitive liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry-parallel reaction monitoring method...

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Detalhes bibliográficos
Main Authors: Zarth, Adam, Cheng, Guang, Zhang, Zhaobin, Wang, Mingyao, Villalta, Peter W., Balbo, Silvia, Hecht, Stephen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022132/
https://ncbi.nlm.nih.gov/pubmed/24632417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2014.03.002
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