USP8 modulates ubiquitination of LRIG1 for Met degradation

The Met receptor tyrosine kinase is an attractive target for cancer therapy as it promotes invasive tumor growth. SAIT301 is a novel anti-Met antibody, which induces LRIG1-mediated Met degradation and inhibits tumor growth. However, detailed downstream mechanism by which LRIG1 mediates target protei...

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Detalhes bibliográficos
Main Authors: Oh, Young Mi, Lee, Saet Byoul, Choi, Jaehyun, Suh, Hye-Young, Shim, Seonhui, Song, Yun-Jeong, Kim, Bogyou, Lee, Ji Min, Oh, Seung Ja, Jeong, Yunju, Cheong, Kwang Ho, Song, Paul H., Kim, Kyung-Ah
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021411/
https://ncbi.nlm.nih.gov/pubmed/24828152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04980
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