Wnt/β-catenin signaling in T-cells drives epigenetic imprinting of pro-inflammatory properties and promotes colitis and colon cancer

The density and type of lymphocytes that infiltrate colon tumors are predictive of the clinical outcome of colon cancer. High densities of TH17 cells and inflammation predict poor outcome, while infiltration by Tregs that naturally suppress inflammation is associated with longer patient survival. Ho...

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Detalhes bibliográficos
Principais autores: Keerthivasan, Shilpa, Aghajani, Katayoun, Dose, Marei, Molinero, Luciana, Khan, Mohammad W., Venkatesvaran, Vysak, Weber, Christopher, Emmanuel, Akinola Olumide, Sun, Tianjao, Ramos, Elena M., Keshavarzian, Ali, Mulcahy, Mary, Blatner, Nichole, Khazaie, Khashayarsha, Gounari, Fotini
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020714/
https://ncbi.nlm.nih.gov/pubmed/24574339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007607
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