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mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
Age-related declines in hematopoietic stem cell (HSC) function may contribute to anemia, poor response to vaccination, and tumorigenesis. Here, we show that mammalian target of rapamycin (mTOR) activity is increased in HSCs from old mice compared to those from young mice. mTOR activation through con...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4020596/ https://ncbi.nlm.nih.gov/pubmed/19934433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000559 |
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