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mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

Age-related declines in hematopoietic stem cell (HSC) function may contribute to anemia, poor response to vaccination, and tumorigenesis. Here, we show that mammalian target of rapamycin (mTOR) activity is increased in HSCs from old mice compared to those from young mice. mTOR activation through con...

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Detaylı Bibliyografya
Asıl Yazarlar: Chen, Chong, Liu, Yu, Liu, Yang, Zheng, Pan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020596/
https://ncbi.nlm.nih.gov/pubmed/19934433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000559
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