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Exploration of sequence space as the basis of viral RNA genome segmentation

The mechanisms of viral RNA genome segmentation are unknown. On extensive passage of foot-and-mouth disease virus in baby hamster kidney-21 cells, the virus accumulated multiple point mutations and underwent a transition akin to genome segmentation. The standard single RNA genome molecule was replac...

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Bibliografske podrobnosti
Main Authors: Moreno, Elena, Ojosnegros, Samuel, García-Arriaza, Juan, Escarmís, Cristina, Domingo, Esteban, Perales, Celia
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020086/
https://ncbi.nlm.nih.gov/pubmed/24757055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323136111
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