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Biological Effect of Muller's Ratchet: Distant Capsid Site Can Affect Picornavirus Protein Processing

Repeated bottleneck passages of RNA viruses result in accumulation of mutations and fitness decrease. Here, we show that clones of foot-and-mouth disease virus (FMDV) subjected to bottleneck passages, in the form of plaque-to-plaque transfers in BHK-21 cells, increased the thermosensitivity of the v...

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Hlavní autoři: Escarmís, Cristina, Perales, Celia, Domingo, Esteban
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698577/
https://ncbi.nlm.nih.gov/pubmed/19403672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00538-09
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