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Biological Effect of Muller's Ratchet: Distant Capsid Site Can Affect Picornavirus Protein Processing
Repeated bottleneck passages of RNA viruses result in accumulation of mutations and fitness decrease. Here, we show that clones of foot-and-mouth disease virus (FMDV) subjected to bottleneck passages, in the form of plaque-to-plaque transfers in BHK-21 cells, increased the thermosensitivity of the v...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology (ASM)
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2698577/ https://ncbi.nlm.nih.gov/pubmed/19403672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00538-09 |
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