Single-molecule analysis reveals human UV-damaged DNA-binding protein (UV-DDB) dimerizes on DNA via multiple kinetic intermediates

How human DNA repair proteins survey the genome for UV-induced photoproducts remains a poorly understood aspect of the initial damage recognition step in nucleotide excision repair (NER). To understand this process, we performed single-molecule experiments, which revealed that the human UV-damaged D...

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Bibliografske podrobnosti
Main Authors: Ghodke, Harshad, Wang, Hong, Hsieh, Ching L., Woldemeskel, Selamawit, Watkins, Simon C., Rapić-Otrin, Vesna, Van Houten, Bennett
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020048/
https://ncbi.nlm.nih.gov/pubmed/24760829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323856111
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