Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair

UV light-induced photoproducts are recognized and removed by the nucleotide-excision repair (NER) pathway. In humans, the UV-damaged DNA-binding protein (UV-DDB) is part of a ubiquitin E3 ligase complex (DDB1-CUL4A(DDB2)) that initiates NER by recognizing damaged chromatin with concomitant ubiquitin...

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Bibliographic Details
Main Authors: Yeh, Joanne I., Levine, Arthur S., Du, Shoucheng, Chinte, Unmesh, Ghodke, Harshad, Wang, Hong, Shi, Haibin, Hsieh, Ching L., Conway, James F., Van Houten, Bennett, Rapić-Otrin, Vesna
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478663/
https://ncbi.nlm.nih.gov/pubmed/22822215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110067109
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