The DDB1-CUL4A(DDB2) ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites

Xeroderma pigmentosum (XP) is a heritable human disorder characterized by defects in nucleotide excision repair (NER) and the development of skin cancer. Cells from XP group E (XP-E) patients have a defect in the UV-damaged DNA-binding protein complex (UV-DDB), involved in the damage recognition ste...

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Main Authors: G. Kapetanaki, Maria, Guerrero-Santoro, Jennifer, Bisi, Dawn C., Hsieh, Ching L., Rapić-Otrin, Vesna, Levine, Arthur S.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2006
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413840/
https://ncbi.nlm.nih.gov/pubmed/16473935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511160103
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