Suppression of InsP(3) Receptor-Mediated Ca(2+) Signaling Alleviates Mutant Presenilin-Linked Familial Alzheimer's Disease Pathogenesis

Exaggerated intracellular Ca(2+) signaling is a robust proximal phenotype observed in cells expressing familial Alzheimer's disease (FAD)-causing mutant presenilins (PSs). The mechanisms that underlie this phenotype are controversial and their in vivo relevance for AD pathogenesis is unknown. H...

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Bibliographic Details
Main Authors: Shilling, Dustin, Müller, Marioly, Takano, Hajime, Daniel Mak, Don-On, Abel, Ted, Coulter, Douglas A., Foskett, J. Kevin
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019804/
https://ncbi.nlm.nih.gov/pubmed/24828645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5441-13.2014
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