Mechanism of Protection by Soluble Epoxide Hydrolase Inhibition in Type 2 Diabetic Stroke

Inhibition of soluble epoxide hydrolase (sEH) is a potential target of therapy for ischemic injury. sEH metabolizes neuroprotective epoxyeicosatrienoic acids (EETs). We recently demonstrated that sEH inhibition reduces infarct size after middle cerebral artery occlusion (MCAO) in type 1 diabetic mic...

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Autori principali: Zuloaga, Kristen L., Krasnow, Stephanie M., Zhu, Xinxia, Zhang, Wenri, Jouihan, Sari A., Shangraw, Robert E., Alkayed, Nabil J., Marks, Daniel L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019567/
https://ncbi.nlm.nih.gov/pubmed/24824753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097529
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